MolNFT v1 · #17432 · protein + DNA
The O. nova telomere end binding protein complexed with single strand DNA
1OTC · DNA (5'-D(*GP*GP*GP*GP*TP*TP*TP*TP*GP*GP*GP*G)-3'): “The O. nova telomere end binding protein complexed with single strand DNA”. X-ray diffraction, 6 pockets (best druggability 0.82). MolNFT v1 #17432 on GenesisL1: 3D structure…
- PDB
- 1OTC
- Type
- protein + DNA
- Length
- 684 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA (5'-D(*GP*GP*GP*GP*TP*TP*TP*TP*GP*GP*GP*G)-3'); Protein (telomere-binding protein…
- UniProt
- P29549, P16458
- Pockets
- 6 · best druggability 0.82
Structure
x-ray diffraction · 3 distinct chains · 21% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| D | DNA (5'-D(*GP*GP*GP*GP*TP*TP*TP*TP*GP*GP*GP*G)-3') | dna | 12 | — | — |
| A | Protein (telomere-binding protein alpha subunit) | protein | 459 | 18% helix, 36% strand | P29549 |
| B | Protein (telomere-binding protein beta subunit) | protein | 213 | 28% helix, 19% strand | P16458 |
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 504 | 0.82 | 0.89 | 54 | empty |
| 2 | 460 | 0.64 | 0.77 | 50 | empty |
| 3 | 152 | 0.47 | 0.77 | 19 | empty |
| 4 | 76 | 0.38 | 0.77 | 17 | empty |
| 5 | 73 | 0.35 | 0.77 | 15 | empty |
Interfaces
3 interfaces between chains.
- A–B · 2801 Ų buried · 44 hydrogen bonds · protein-protein
- D–A · 1281 Ų buried · 37 hydrogen bonds · protein-nucleic
- D–B · 398 Ų buried · 11 hydrogen bonds · protein-nucleic
Compared structures
- 1OTC · The O. nova telomere end binding protein complexed with single strand DNA · the same entry in another collection · chain D against D, TM-score 1.00
- P29549 · AlphaFold monomer V2.0 prediction for telomere-binding protein subunit alpha (P29549) · a predicted model of the same protein · chain A against A, TM-score 0.98
- P16458 · AlphaFold monomer V2.0 prediction for telomere-binding protein subunit beta (P16458) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P29549
- Every structure of UniProt P16458
- Elsewhere: RCSB PDB 1OTC · PDBe 1OTC · UniProt P29549 · UniProt P16458
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