MolNFT v1 · #174314 · protein
Atrial natriuretic peptide receptor complexed with deletion mutant of rat atrial natriuretic PEPTIDE[4-17,23]
7BRL · Atrial natriuretic peptide receptor 1: “Atrial natriuretic peptide receptor complexed with deletion mutant of rat atrial natriuretic PEPTIDE[4-17,23]”. X-ray diffraction, 3 ligands (NAG, MAN, CL), 6 pockets (best druggability 0.71).…
- PDB
- 7BRL
- Type
- protein
- Length
- 867 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Atrial natriuretic peptide receptor 1; Natriuretic peptides a
- EC
- 4.6.1.2
- UniProt
- P18910, P01161
- Ligands
- NAG, MAN, CL
- Pockets
- 6 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 36% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Atrial natriuretic peptide receptor 1 (EC 4.6.1.2) | protein | 426 | 38% helix, 19% strand | P18910 |
| L | Natriuretic peptides a | protein | 15 | 0% helix, 0% strand | P01161 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 8 copies · chains A, B
- MAN · alpha-D-mannopyranose · sugar · 6 copies · chains B
- CL · Chloride ion · ion · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 611 | 0.71 | 0.79 | 81 | empty |
| 2 | 632 | 0.70 | 0.78 | 78 | empty |
| 3 | 87 | 0.61 | 0.89 | 21 | empty |
| 4 | 79 | 0.59 | 0.88 | 20 | empty |
| 5 | 204 | 0.50 | 0.76 | 36 | empty |
Interfaces
3 interfaces between chains.
- B–L · 635 Ų buried · 3 hydrogen bonds · protein-protein
- A–B · 590 Ų buried · 3 hydrogen bonds · protein-protein
- A–L · 518 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide, 4 glycan (disulfide, N-glycosylation).
Compared structures
- 7BRL · Atrial Natriuretic Peptide Receptor complexed with Deletion mutant of rat Atrial… · the same entry in another collection · chain A against A, TM-score 1.00
- P18910 · AlphaFold monomer V2.0 prediction for atrial natriuretic peptide receptor 1 (P18910) · a predicted model of the same protein · chain A against A, TM-score 0.99
- P01161 · AlphaFold monomer V2.0 prediction for natriuretic peptides a (P01161) · a predicted model of the same protein · chain L against A, TM-score 0.20
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P18910
- Every structure of UniProt P01161
- Elsewhere: RCSB PDB 7BRL · PDBe 7BRL · UniProt P18910 · UniProt P01161
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