MolNFT v1 · #174311 · protein
Atrial natriuretic peptide receptor complexed with dendroaspis natriuretic peptide
7BRI · Atrial natriuretic peptide receptor 1: “Atrial natriuretic peptide receptor complexed with dendroaspis natriuretic peptide”. X-ray diffraction, 3 ligands (NAG, MAN, CL), 11 pockets (best druggability 0.64). MolNFT v1 #174311 on…
- PDB
- 7BRI
- Type
- protein
- Length
- 881 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Atrial natriuretic peptide receptor 1; Natriuretic peptide dnp
- EC
- 4.6.1.2
- UniProt
- P18910, P28374
- Ligands
- NAG, MAN, CL
- Pockets
- 11 · best druggability 0.64
Structure
x-ray diffraction · 2 distinct chains · 36% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Atrial natriuretic peptide receptor 1 (EC 4.6.1.2) | protein | 426 | 38% helix, 20% strand | P18910 |
| L | Natriuretic peptide dnp | protein | 29 | 14% helix, 3% strand | P28374 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 8 copies · chains A, B
- MAN · alpha-D-mannopyranose · sugar · 6 copies
- CL · Chloride ion · ion · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 266 | 0.64 | 0.81 | 39 | empty |
| 2 | 268 | 0.64 | 0.81 | 38 | empty |
| 3 | 102 | 0.58 | 0.86 | 25 | empty |
| 4 | 259 | 0.57 | 0.78 | 41 | empty |
| 5 | 102 | 0.55 | 0.84 | 25 | empty |
Interfaces
3 interfaces between chains.
- B–L · 1246 Ų buried · 11 hydrogen bonds · protein-protein
- A–L · 902 Ų buried · 13 hydrogen bonds · protein-protein
- A–B · 546 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide, 4 glycan (disulfide, N-glycosylation).
Compared structures
- 7BRI · Atrial Natriuretic Peptide Receptor complexed with Dendroaspis Natriuretic Peptide · the same entry in another collection · chain A against A, TM-score 1.00
- P18910 · AlphaFold monomer V2.0 prediction for atrial natriuretic peptide receptor 1 (P18910) · a predicted model of the same protein · chain B against A, TM-score 0.99
- P28374 · AlphaFold monomer V2.0 prediction for natriuretic peptide dnp (P28374) · a predicted model of the same protein · chain L against A, TM-score 0.25
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P18910
- Every structure of UniProt P28374
- Elsewhere: RCSB PDB 7BRI · PDBe 7BRI · UniProt P18910 · UniProt P28374
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