MolNFT v1 · #174310 · protein
Atrial natriuretic peptide receptor complexed with human atrial natriuretic peptide
7BRH · Atrial natriuretic peptide receptor 1: “Atrial natriuretic peptide receptor complexed with human atrial natriuretic peptide”. X-ray diffraction, 3 ligands (NAG, MAN, CL), 10 pockets (best druggability 0.68). MolNFT v1 #174310 on…
- PDB
- 7BRH
- Type
- protein
- Length
- 877 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Atrial natriuretic peptide receptor 1; Natriuretic peptides a
- EC
- 4.6.1.2
- UniProt
- P18910, P01160
- Ligands
- NAG, MAN, CL
- Pockets
- 10 · best druggability 0.68
Structure
x-ray diffraction · 2 distinct chains · 36% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Atrial natriuretic peptide receptor 1 (EC 4.6.1.2) | protein | 426 | 38% helix, 19% strand | P18910 |
| L | Natriuretic peptides a | protein | 25 | 16% helix, 4% strand | P01160 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 8 copies · chains A, B
- MAN · alpha-D-mannopyranose · sugar · 6 copies
- CL · Chloride ion · ion · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 405 | 0.68 | 0.80 | 57 | empty |
| 2 | 324 | 0.68 | 0.82 | 39 | empty |
| 3 | 313 | 0.66 | 0.81 | 40 | empty |
| 4 | 99 | 0.62 | 0.88 | 22 | empty |
| 5 | 98 | 0.61 | 0.88 | 22 | empty |
Interfaces
3 interfaces between chains.
- B–L · 1071 Ų buried · 10 hydrogen bonds · protein-protein
- A–L · 853 Ų buried · 9 hydrogen bonds · protein-protein
- A–B · 557 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide, 4 glycan (disulfide, N-glycosylation).
Compared structures
- 7BRH · Atrial Natriuretic Peptide Receptor complexed with human Atrial Natriuretic Peptide · the same entry in another collection · chain A against A, TM-score 1.00
- P18910 · AlphaFold monomer V2.0 prediction for atrial natriuretic peptide receptor 1 (P18910) · a predicted model of the same protein · chain B against A, TM-score 0.99
- P01160 · AlphaFold monomer V2.0 prediction for natriuretic peptides a (P01160) · a predicted model of the same protein · chain L against A, TM-score 0.17
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P18910
- Every structure of UniProt P01160
- Elsewhere: RCSB PDB 7BRH · PDBe 7BRH · UniProt P18910 · UniProt P01160
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