Crystal structure of the protein 1

Structure

x-ray diffraction · 1 distinct chain · 64% helix, 8% strand (DSSP).

Ligands and binding sites

• 1QW · (2R)-2,3-dihydroxypropyl dodecanoate · ligand · chains A
• F5O · 4-[[(1R)-2-[5-(2-fluoranyl-3-methoxy-phenyl)-3-[[2-fluoranyl-6-(trifluoromethyl)phenyl]methyl]-4-methyl-2,6-bis(oxidanylidene)pyrimidin-1-yl]-1-phenyl-ethyl]amino]butanoic acid · ligand · chains A
• PEG · Di(hydroxyethyl)ether · additive · 6 copies · chains A
• OLC · (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate · additive · 2 copies · chains A
• FMT · Formic acid · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

• 7BR3 · Crystal structure of the protein 1 · the same entry in another collection · chain A against A, TM-score 1.00
• P30968 · AlphaFold monomer V2.0 prediction for gonadotropin-releasing hormone receptor (P30968) · a predicted model of the same protein · chain A against A, TM-score 0.54

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P30968
• Every structure of UniProt Q9V2J8
• Elsewhere: RCSB PDB 7BR3 · PDBe 7BR3 · UniProt P30968 · UniProt Q9V2J8