MolNFT v1 · #174266 · protein
Zikv se bound to mab Z6
7BQ5 · Envelope protein: “Zikv se bound to mab Z6”. X-ray diffraction, 19 pockets (best druggability 0.67). MolNFT v1 #174266 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7BQ5
- Type
- protein
- Length
- 1,638 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Envelope protein; Z6 heavy chain; Z6 light chain
- UniProt
- A0A142I5B9
- Pockets
- 19 · best druggability 0.67
Structure
x-ray diffraction · 3 distinct chains · 5% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Envelope protein | protein | 390 | 5% helix, 48% strand | A0A142I5B9 |
| H, C | Z6 heavy chain | protein | 218 | 1% helix, 51% strand | — |
| L, D | Z6 light chain | protein | 211 | 7% helix, 51% strand | — |
Pockets
19 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 757 | 0.67 | 0.75 | 58 | empty |
| 2 | 658 | 0.65 | 0.75 | 63 | empty |
| 3 | 52 | 0.64 | 0.95 | 20 | empty |
| 4 | 361 | 0.59 | 0.77 | 50 | empty |
| 5 | 229 | 0.57 | 0.79 | 32 | empty |
Interfaces
11 interfaces between chains.
- H–L · 1913 Ų buried · 13 hydrogen bonds · protein-protein
- C–D · 1897 Ų buried · 13 hydrogen bonds · protein-protein
- B–D · 396 Ų buried · 5 hydrogen bonds · protein-protein
- A–L · 394 Ų buried · 4 hydrogen bonds · protein-protein
- A–H · 258 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 20 disulfide (disulfide).
Compared structures
- 7BQ5 · ZIKV sE bound to mAb Z6 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A142I5B9
- Elsewhere: RCSB PDB 7BQ5 · PDBe 7BQ5 · UniProt A0A142I5B9
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.