MolNFT v1 · #174148 · protein
Crystal structure of a R18W mutant of the DNA-binding protein rema from geobacillus thermodenitrificans
7BME · Putative regulatory protein GTNG_1019: “Crystal structure of a R18W mutant of the DNA-binding protein rema from geobacillus thermodenitrificans”. X-ray diffraction, 9 pockets (best druggability 0.61). MolNFT v1 #174148 on GenesisL1…
- PDB
- 7BME
- Type
- protein
- Length
- 529 residues
- Chains
- 7
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Putative regulatory protein GTNG_1019
- UniProt
- A4IM41
- Pockets
- 9 · best druggability 0.61
Structure
x-ray diffraction · 5 distinct chains · 28% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, G | Putative regulatory protein GTNG_1019 | protein | 75 | 28% helix, 31% strand | A4IM41 |
| B, E | Putative regulatory protein GTNG_1019 | protein | 77 | 29% helix, 30% strand | A4IM41 |
| C | Putative regulatory protein GTNG_1019 | protein | 75 | 28% helix, 31% strand | A4IM41 |
| D | Putative regulatory protein GTNG_1019 | protein | 74 | 26% helix, 32% strand | A4IM41 |
| F | Putative regulatory protein GTNG_1019 | protein | 76 | 29% helix, 30% strand | A4IM41 |
Pockets
9 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 641 | 0.61 | 0.73 | 60 | empty |
| 2 | 84 | 0.50 | 0.83 | 13 | empty |
| 3 | 53 | 0.47 | 0.85 | 14 | empty |
| 4 | 74 | 0.45 | 0.81 | 14 | empty |
| 5 | 80 | 0.43 | 0.80 | 15 | empty |
Interfaces
7 interfaces between chains.
- A–B · 949 Ų buried · 10 hydrogen bonds · protein-protein
- E–F · 945 Ų buried · 13 hydrogen bonds · protein-protein
- B–C · 938 Ų buried · 9 hydrogen bonds · protein-protein
- D–G · 913 Ų buried · 13 hydrogen bonds · protein-protein
- C–E · 911 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 7BME · Crystal structure of a R18W mutant of the DNA-binding protein RemA from Geobacillus… · the same entry in another collection · chain G against G, TM-score 1.00
- A4IM41 · AlphaFold monomer V2.0 prediction for putative regulatory protein GTNG_1019 (A4IM41) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A4IM41
- Elsewhere: RCSB PDB 7BME · PDBe 7BME · UniProt A4IM41
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