MolNFT v1 · #174125 · protein
VPS35/VPS29 arch of fungal membrane-assembled RETROMER:VPS5 (snx-bar) complex.
7BLR · Vacuolar protein sorting-associated protein 35: “VPS35/VPS29 arch of fungal membrane-assembled RETROMER:VPS5 (snx-bar) complex.”. Electron microscopy, 20 pockets (best druggability 0.88). MolNFT v1 #174125 on GenesisL1: 3D…
- PDB
- 7BLR
- Type
- protein
- Length
- 1,870 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Vacuolar protein sorting-associated protein 35; Vacuolar protein sorting-associated…
- UniProt
- G0S709, G0RZB5
- Pockets
- 20 · best druggability 0.88
Structure
electron microscopy · 2 distinct chains · 60% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Vacuolar protein sorting-associated protein 35 | protein | 748 | 71% helix, 1% strand | G0S709 |
| B, D | Vacuolar protein sorting-associated protein 29 | protein | 187 | 14% helix, 26% strand | G0RZB5 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1035 | 0.88 | 0.89 | 151 | empty |
| 2 | 889 | 0.85 | 0.87 | 106 | empty |
| 3 | 545 | 0.84 | 0.89 | 90 | empty |
| 4 | 536 | 0.83 | 0.89 | 87 | empty |
| 5 | 191 | 0.79 | 0.93 | 36 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1515 Ų buried · 14 hydrogen bonds · protein-protein
- C–D · 1263 Ų buried · 12 hydrogen bonds · protein-protein
- A–C · 560 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 7BLR · Vps35/Vps29 arch of fungal membrane-assembled retromer:Vps5 (SNX-BAR) complex. · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G0S709
- Every structure of UniProt G0RZB5
- Elsewhere: RCSB PDB 7BLR · PDBe 7BLR · UniProt G0S709 · UniProt G0RZB5
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