MolNFT v1 · #17412 · DNA

Structural study of DNA duplex containaing a N-(2-deoxy-beta-erytho- pentofuranosyl) formamide frameshift by NMR and restrained molecular dynamics

1OSR · 5'-D(*AP*GP*GP*AP*CP*CP*AP*CP*G)-3': “Structural study of DNA duplex containaing a N-(2-deoxy-beta-erytho- pentofuranosyl) formamide frameshift by…”. Solution nmr, 1 pocket (best druggability 0.24). MolNFT v1 #17412 on GenesisL1: 3D…

PDB: 1OSR
Type: DNA
Length: 19 nucleotides
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 5'-D(*AP*GP*GP*AP*CP*CP*AP*CP*G)-3'; 5'-D(*CP*GP*TP*GP*GP*(2DF)P*TP*CP*CP*T)-3'
Pockets: 1 · best druggability 0.24

Structure

solution nmr · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	5'-D(APGPGPAPCPCPAPCP*G)-3'	dna	9	—	—
B	5'-D(CPGPTPGPGP(2DF)PTPCPCPT)-3'	dna	10	—	—

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	59	0.24	0.72	15	empty

Interfaces

1 interface between chains.

A–B · 406 Å² buried · 43 hydrogen bonds · nucleic-nucleic

Modifications

Observed in the structure: 1 modified (nucleotide modification).

Compared structures

1OSR · Structural study of dna duplex containaing a n-(2-deoxy-beta-erytho-pentofuranosyl)… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 1OSR · PDBe 1OSR

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.