MolNFT v1 · #174025 · protein

Crystal structure of nematocida HUWE1

7BII · E3 ubiquitin-protein ligase HUWE1: “Crystal structure of nematocida HUWE1”. X-ray diffraction, 20 pockets (best druggability 0.77). MolNFT v1 #174025 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7BII
Type: protein
Length: 4,287 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: E3 ubiquitin-protein ligase HUWE1
UniProt: A0A177ELV2
Pockets: 20 · best druggability 0.77

Structure

x-ray diffraction · 2 distinct chains · 65% helix, 3% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	E3 ubiquitin-protein ligase HUWE1	protein	2143	65% helix, 3% strand	A0A177ELV2
B	E3 ubiquitin-protein ligase HUWE1	protein	2144	66% helix, 3% strand	A0A177ELV2

Pockets

20 pockets found on a 1 Å grid, 16 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1145	0.77	0.79	88	empty
2	1004	0.76	0.79	58	empty
3	885	0.73	0.77	69	empty
4	784	0.73	0.78	78	empty
5	1023	0.72	0.76	81	empty

Interfaces

1 interface between chains.

A–B · 621 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

7BII · Crystal structure of Nematocida HUWE1 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A177ELV2
Elsewhere: RCSB PDB 7BII · PDBe 7BII · UniProt A0A177ELV2

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