MolNFT v1 · #174024 · protein
Crystal structure of recj-CDC45 from methanothermobacter thermoautotrophicus in the closed state.
7BIH · Conserved protein: “Crystal structure of recj-CDC45 from methanothermobacter thermoautotrophicus in the closed state.”. X-ray diffraction, 2 ligands (MN, PO4), 7 pockets (best druggability 0.84). MolNFT v1 #174024 on GenesisL1: 3D…
- PDB
- 7BIH
- Type
- protein
- Length
- 887 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Conserved protein
- UniProt
- O27473
- Ligands
- MN, PO4
- Pockets
- 7 · best druggability 0.84
Structure
x-ray diffraction · 2 distinct chains · 50% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Conserved protein | protein | 444 | 50% helix, 16% strand | O27473 |
| B | Conserved protein | protein | 443 | 50% helix, 16% strand | O27473 |
Ligands and binding sites
- MN · Manganese (II) ion · metal · 4 copies · chains A, B
- PO4 · Phosphate ion · ion · 2 copies · chains A, B
- PEG · Di(hydroxyethyl)ether · additive · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1098 | 0.84 | 0.85 | 94 | PO4 |
| 2 | 1102 | 0.82 | 0.83 | 101 | MN, PO4 |
| 3 | 592 | 0.78 | 0.84 | 65 | PEG |
| 4 | 67 | 0.57 | 0.89 | 25 | empty |
| 5 | 55 | 0.49 | 0.86 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 527 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 7BIH · Crystal structure of RecJ-Cdc45 from Methanothermobacter Thermoautotrophicus in the… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O27473
- Elsewhere: RCSB PDB 7BIH · PDBe 7BIH · UniProt O27473
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