MolNFT v1 · #17400 · protein

Crystal structure of rat CUTA1 at 2.15 a resolution

1OSC · Similar to divalent cation tolerant protein cuta: “Crystal structure of rat CUTA1 at 2.15 a resolution”. X-ray diffraction, 13 pockets (best druggability 0.80). MolNFT v1 #17400 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 1OSC
Type: protein
Length: 655 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Similar to divalent cation tolerant protein cuta
UniProt: Q6MGD0
Pockets: 13 · best druggability 0.80

Structure

x-ray diffraction · 5 distinct chains · 33% helix, 41% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C	Similar to divalent cation tolerant protein cuta	protein	108	33% helix, 42% strand	Q6MGD0
B	Similar to divalent cation tolerant protein cuta	protein	109	33% helix, 41% strand	Q6MGD0
D	Similar to divalent cation tolerant protein cuta	protein	109	31% helix, 41% strand	Q6MGD0
E	Similar to divalent cation tolerant protein cuta	protein	110	33% helix, 40% strand	Q6MGD0
F	Similar to divalent cation tolerant protein cuta	protein	111	32% helix, 41% strand	Q6MGD0

Pockets

13 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	209	0.80	0.94	56	empty
2	266	0.59	0.79	37	empty
3	150	0.57	0.82	24	empty
4	116	0.55	0.83	18	empty
5	137	0.55	0.81	17	empty

Interfaces

12 interfaces between chains.

E–F · 1233 Å² buried · 18 hydrogen bonds · protein-protein
A–C · 1227 Å² buried · 14 hydrogen bonds · protein-protein
A–B · 1198 Å² buried · 14 hydrogen bonds · protein-protein
D–F · 1193 Å² buried · 15 hydrogen bonds · protein-protein
D–E · 1174 Å² buried · 17 hydrogen bonds · protein-protein

Compared structures

1OSC · Crystal structure of rat CUTA1 at 2.15 A resolution · the same entry in another collection · chain F against F, TM-score 1.00
Q6MGD0 · AlphaFold monomer V2.0 prediction for protein cuta (Q6MGD0) · a predicted model of the same protein · chain C against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6MGD0
Elsewhere: RCSB PDB 1OSC · PDBe 1OSC · UniProt Q6MGD0

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