MolNFT v1 · #173928 · protein

Circular permutant of ribosomal protein S6, P54-55 truncated, I25A mutant.

7BFF · 30S ribosomal protein S6,30S ribosomal protein S6: “Circular permutant of ribosomal protein S6, P54-55 truncated, I25A mutant.”. X-ray diffraction, 4 pockets (best druggability 0.42). MolNFT v1 #173928 on GenesisL1: 3D structure…

PDB: 7BFF
Type: protein
Length: 509 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 30S ribosomal protein S6,30S ribosomal protein S6
UniProt: Q5SLP8
Pockets: 4 · best druggability 0.42

Structure

x-ray diffraction · 4 distinct chains · 35% helix, 38% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	30S ribosomal protein S6,30S ribosomal protein S6	protein	84	36% helix, 38% strand	Q5SLP8
B, C	30S ribosomal protein S6,30S ribosomal protein S6	protein	86	34% helix, 37% strand	Q5SLP8
D, F	30S ribosomal protein S6,30S ribosomal protein S6	protein	85	35% helix, 38% strand	Q5SLP8
E	30S ribosomal protein S6,30S ribosomal protein S6	protein	83	35% helix, 39% strand	Q5SLP8

Pockets

4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	90	0.42	0.78	21	empty
2	75	0.39	0.78	18	empty
3	80	0.33	0.74	16	empty
4	62	0.30	0.74	17	empty

Interfaces

5 interfaces between chains.

D–E · 743 Å² buried · 14 hydrogen bonds · protein-protein
C–D · 724 Å² buried · 17 hydrogen bonds · protein-protein
A–B · 717 Å² buried · 15 hydrogen bonds · protein-protein
C–F · 684 Å² buried · 13 hydrogen bonds · protein-protein
B–E · 634 Å² buried · 13 hydrogen bonds · protein-protein

Compared structures

7BFF · Circular permutant of ribosomal protein S6, P54-55 truncated, I25A mutant. · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5SLP8
Elsewhere: RCSB PDB 7BFF · PDBe 7BFF · UniProt Q5SLP8

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