MolNFT v1 · #173925 · protein
Circular permutant of ribosomal protein S6, P54-55 truncated,
7BFC · 30S ribosomal protein S6,30S ribosomal protein S6: “Circular permutant of ribosomal protein S6, P54-55 truncated,”. X-ray diffraction, 19 pockets (best druggability 0.48). MolNFT v1 #173925 on GenesisL1: 3D structure, binding sites…
- PDB
- 7BFC
- Type
- protein
- Length
- 1,200 residues
- Chains
- 14
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 30S ribosomal protein S6,30S ribosomal protein S6
- UniProt
- Q5SLP8
- Pockets
- 19 · best druggability 0.48
Structure
x-ray diffraction · 2 distinct chains · 33% helix, 37% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C, N, B, A, D, E, I, G, H, L | 30S ribosomal protein S6,30S ribosomal protein S6 | protein | 86 | 33% helix, 37% strand | Q5SLP8 |
| M, J, K, F | 30S ribosomal protein S6,30S ribosomal protein S6 | protein | 85 | 33% helix, 38% strand | Q5SLP8 |
Pockets
19 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 244 | 0.48 | 0.74 | 28 | empty |
| 2 | 87 | 0.44 | 0.80 | 15 | empty |
| 3 | 99 | 0.42 | 0.78 | 19 | empty |
| 4 | 145 | 0.41 | 0.74 | 24 | empty |
| 5 | 85 | 0.40 | 0.77 | 14 | empty |
Interfaces
17 interfaces between chains.
- B–A · 807 Ų buried · 15 hydrogen bonds · protein-protein
- M–L · 786 Ų buried · 20 hydrogen bonds · protein-protein
- N–M · 773 Ų buried · 19 hydrogen bonds · protein-protein
- I–H · 763 Ų buried · 15 hydrogen bonds · protein-protein
- D–E · 739 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 7BFC · Circular permutant of ribosomal protein S6, P54-55 truncated, · the same entry in another collection · chain C against C, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5SLP8
- Elsewhere: RCSB PDB 7BFC · PDBe 7BFC · UniProt Q5SLP8
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