MolNFT v1 · #17381 · protein
X-ray structure of the kvap potassium channel voltage sensor in complex with an Fab
1ORS · 33H1 Fab light chain: “X-ray structure of the kvap potassium channel voltage sensor in complex with an Fab”. X-ray diffraction, 6 pockets (best druggability 0.54). MolNFT v1 #17381 on GenesisL1: 3D structure, binding sites and…
- PDB
- 1ORS
- Type
- protein
- Length
- 567 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 33H1 Fab light chain; 33H1 Fab heavy chain; Potassium channel
- UniProt
- P01837, P01869, Q9YDF8
- Pockets
- 6 · best druggability 0.54
Structure
x-ray diffraction · 3 distinct chains · 23% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 33H1 Fab light chain | protein | 214 | 8% helix, 57% strand | P01837 |
| B | 33H1 Fab heavy chain | protein | 221 | 5% helix, 51% strand | P01869 |
| C | Potassium channel | protein | 132 | 77% helix, 0% strand | Q9YDF8 |
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 301 | 0.54 | 0.75 | 48 | empty |
| 2 | 70 | 0.44 | 0.81 | 20 | empty |
| 3 | 144 | 0.40 | 0.74 | 23 | empty |
| 4 | 74 | 0.35 | 0.76 | 19 | empty |
| 5 | 76 | 0.30 | 0.73 | 16 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1863 Ų buried · 13 hydrogen bonds · protein-protein
- B–C · 471 Ų buried · 7 hydrogen bonds · protein-protein
- A–C · 92 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 1ORS · X-ray structure of the KvAP potassium channel voltage sensor in complex with an Fab · the same entry in another collection · chain A against A, TM-score 1.00
- Q9YDF8 · AlphaFold monomer V2.0 prediction for voltage-gated potassium channel (Q9YDF8) · a predicted model of the same protein · chain C against A, TM-score 0.88
- P01869 · AlphaFold monomer V2.0 prediction for ig gamma-1 chain C region, membrane-bound form… · a predicted model of the same protein · chain B against A, TM-score 0.51
- P01837 · AlphaFold monomer V2.0 prediction for immunoglobulin kappa constant (P01837) · a predicted model of the same protein · chain A against A, TM-score 0.49
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01837
- Every structure of UniProt P01869
- Every structure of UniProt Q9YDF8
- Elsewhere: RCSB PDB 1ORS · PDBe 1ORS · UniProt P01837 · UniProt P01869 · UniProt Q9YDF8
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