MolNFT v1 · #173748 · protein
Structure of the mycobacterial esx-5 type VII secretion system hexameric pore complex
7B9S · ECCE5: “Structure of the mycobacterial esx-5 type VII secretion system hexameric pore complex”. Electron microscopy, 20 pockets (best druggability 0.85). MolNFT v1 #173748 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 7B9S
- Type
- protein
- Length
- 9,426 residues
- Chains
- 30
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ECCE5; ECCD5; ECCC5; ECCB5
- UniProt
- I0RST0, I0RSS8, I0RZI0, I0RZH9
- Pockets
- 20 · best druggability 0.85
Structure
electron microscopy · 5 distinct chains · 54% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| E, H, M, R, Y, 4 | ECCE5 | protein | 165 | 27% helix, 33% strand | I0RST0 |
| X, I, N, S, Z, 5 | ECCD5 | protein | 462 | 67% helix, 8% strand | I0RSS8 |
| C, F, K, P, V, 2 | ECCC5 | protein | 396 | 39% helix, 20% strand | I0RZI0 |
| D, G, L, Q, W, 3 | ECCD5 | protein | 485 | 60% helix, 8% strand | I0RSS8 |
| B, A, J, O, T, 1 | ECCB5 | protein | 63 | 68% helix, 0% strand | I0RZH9 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1075 | 0.85 | 0.86 | 111 | empty |
| 2 | 859 | 0.84 | 0.86 | 85 | empty |
| 3 | 859 | 0.84 | 0.86 | 93 | empty |
| 4 | 1031 | 0.84 | 0.85 | 93 | empty |
| 5 | 833 | 0.83 | 0.86 | 95 | empty |
Interfaces
84 interfaces between chains.
- N–L · 4169 Ų buried · 23 hydrogen bonds · protein-protein
- 5–3 · 4164 Ų buried · 21 hydrogen bonds · protein-protein
- Z–W · 4161 Ų buried · 22 hydrogen bonds · protein-protein
- I–G · 4153 Ų buried · 24 hydrogen bonds · protein-protein
- X–D · 4153 Ų buried · 20 hydrogen bonds · protein-protein
Compared structures
- 7B9S · Structure of the mycobacterial ESX-5 Type VII Secretion System hexameric pore complex · the same entry in another collection · chain X against X, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt I0RST0
- Every structure of UniProt I0RSS8
- Every structure of UniProt I0RZI0
- Every structure of UniProt I0RZH9
- Elsewhere: RCSB PDB 7B9S · PDBe 7B9S · UniProt I0RST0 · UniProt I0RSS8 · UniProt I0RZI0 · UniProt I0RZH9
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