MolNFT v1 · #173736 · protein
Structure of the mycobacterial esx-5 type VII secretion system hexameric pore complex
7B9F · ECCE5: “Structure of the mycobacterial esx-5 type VII secretion system hexameric pore complex”. Electron microscopy, 20 pockets (best druggability 0.69). MolNFT v1 #173736 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 7B9F
- Type
- protein
- Length
- 1,475 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ECCE5; ECCD5; ECCC5; ECCB5
- UniProt
- I0RST0, I0RSS8, I0RZI0, I0RZH9
- Pockets
- 20 · best druggability 0.69
Structure
electron microscopy · 5 distinct chains · 53% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| E | ECCE5 | protein | 165 | 28% helix, 34% strand | I0RST0 |
| X | ECCD5 | protein | 425 | 66% helix, 8% strand | I0RSS8 |
| C | ECCC5 | protein | 337 | 32% helix, 23% strand | I0RZI0 |
| D | ECCD5 | protein | 485 | 63% helix, 8% strand | I0RSS8 |
| B | ECCB5 | protein | 63 | 67% helix, 0% strand | I0RZH9 |
Pockets
20 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 583 | 0.69 | 0.78 | 49 | empty |
| 2 | 298 | 0.68 | 0.83 | 34 | empty |
| 3 | 469 | 0.68 | 0.79 | 54 | empty |
| 4 | 282 | 0.67 | 0.82 | 31 | empty |
| 5 | 500 | 0.65 | 0.77 | 39 | empty |
Interfaces
8 interfaces between chains.
- X–D · 4115 Ų buried · 20 hydrogen bonds · protein-protein
- C–D · 1608 Ų buried · 9 hydrogen bonds · protein-protein
- D–B · 1374 Ų buried · 9 hydrogen bonds · protein-protein
- X–C · 1150 Ų buried · 18 hydrogen bonds · protein-protein
- E–X · 885 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 7B9F · Structure of the mycobacterial ESX-5 Type VII Secretion System hexameric pore complex · the same entry in another collection · chain E against E, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt I0RST0
- Every structure of UniProt I0RSS8
- Every structure of UniProt I0RZI0
- Every structure of UniProt I0RZH9
- Elsewhere: RCSB PDB 7B9F · PDBe 7B9F · UniProt I0RST0 · UniProt I0RSS8 · UniProt I0RZI0 · UniProt I0RZH9
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