MolNFT v1 · #173716 · protein

Circular permutant of ribosomal protein S6, P54-55

7B8V · 30S ribosomal protein S6: “Circular permutant of ribosomal protein S6, P54-55”. X-ray diffraction, 20 pockets (best druggability 0.72). MolNFT v1 #173716 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7B8V
Type: protein
Length: 2,040 residues
Chains: 24
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 30S ribosomal protein S6
UniProt: P62666
Pockets: 20 · best druggability 0.72

Structure

x-ray diffraction · 1 distinct chain · 32% helix, 38% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, S, T, W, X, U, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, V	30S ribosomal protein S6	protein	85	32% helix, 38% strand	P62666

Pockets

20 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	897	0.72	0.76	92	empty
2	783	0.69	0.76	86	empty
3	572	0.62	0.74	54	empty
4	496	0.61	0.75	55	empty
5	315	0.60	0.78	33	empty

Interfaces

42 interfaces between chains.

C–H · 707 Å² buried · 11 hydrogen bonds · protein-protein
E–L · 702 Å² buried · 13 hydrogen bonds · protein-protein
U–O · 693 Å² buried · 11 hydrogen bonds · protein-protein
S–X · 684 Å² buried · 13 hydrogen bonds · protein-protein
M–N · 682 Å² buried · 14 hydrogen bonds · protein-protein

Compared structures

7B8V · Circular permutant of ribosomal protein S6, P54-55 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P62666
Elsewhere: RCSB PDB 7B8V · PDBe 7B8V · UniProt P62666

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