MolNFT v1 · #17370 · protein
Structure of the predominant protein arginine methyltransferase PRMT1
1ORH · Protein arginine N-methyltransferase 1: “Structure of the predominant protein arginine methyltransferase PRMT1”. X-ray diffraction, 1 ligand (SAH), 2 pockets (best druggability 0.63). MolNFT v1 #17370 on GenesisL1: 3D structure…
- PDB
- 1ORH
- Type
- protein
- Length
- 328 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein arginine N-methyltransferase 1; Substrate peptide
- EC
- 2.1.1.125
- UniProt
- Q63009
- Ligands
- SAH
- Pockets
- 2 · best druggability 0.63
Structure
x-ray diffraction · 2 distinct chains · 25% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein arginine N-methyltransferase 1 (EC 2.1.1.125) | protein | 318 | 26% helix, 40% strand | Q63009 |
| B | Substrate peptide | protein | 10 | 0% helix, 0% strand | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 325 | 0.63 | 0.79 | 36 | SAH |
| 2 | 73 | 0.43 | 0.80 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 411 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 1ORH · Structure of the Predominant Protein Arginine Methyltransferase PRMT1 · the same entry in another collection · chain A against A, TM-score 1.00
- Q63009 · AlphaFold monomer V2.0 prediction for protein arginine N-methyltransferase 1 (Q63009) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q63009
- Elsewhere: RCSB PDB 1ORH · PDBe 1ORH · UniProt Q63009
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