MolNFT v1 · #173660 · protein
Cryo-EM structure of human thyroglobulin
7B75: “Cryo-EM structure of human thyroglobulin”. Electron microscopy, 3 ligands (NAG, MAN, BMA), 20 pockets (best druggability 0.86). MolNFT v1 #173660 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7B75
- Type
- protein
- Length
- 4,966 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Thyroglobulin
- UniProt
- P01266
- Ligands
- NAG, MAN, BMA
- Pockets
- 20 · best druggability 0.86
Structure
electron microscopy · 1 distinct chain · 24% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Thyroglobulin | protein | 2483 | 24% helix, 16% strand | P01266 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 40 copies · chains A, B
- MAN · alpha-D-mannopyranose · sugar · 8 copies · chains A, B
- BMA · beta-D-mannopyranose · sugar · 6 copies · chains B, A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1073 | 0.86 | 0.87 | 99 | empty |
| 2 | 1140 | 0.86 | 0.87 | 102 | empty |
| 3 | 1199 | 0.83 | 0.84 | 134 | empty |
| 4 | 1118 | 0.82 | 0.84 | 104 | empty |
| 5 | 1181 | 0.82 | 0.83 | 138 | empty |
Interfaces
1 interface between chains.
- A–B · 9643 Ų buried · 77 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 114 disulfide, 28 glycan (disulfide, N-glycosylation).
Compared structures
- 7B75 · Cryo-EM Structure of Human Thyroglobulin · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01266
- Elsewhere: RCSB PDB 7B75 · PDBe 7B75 · UniProt P01266
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