MolNFT v1 · #173653 · protein

Trappcore from the minitrappiii complex

7B6X · Trafficking protein particle complex subunit: “Trappcore from the minitrappiii complex”. Electron microscopy, 20 pockets (best druggability 0.82). MolNFT v1 #173653 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7B6X
Type: protein
Length: 1,290 residues
Chains: 8
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Trafficking protein particle complex subunit; GEO08327P1; Probable trafficking protein…
UniProt: Q9VSY8, Q9VF82, Q9VA95, Q9VLI9, Q9VUZ1, Q7K2Q8, A1Z8I0
Pockets: 20 · best druggability 0.82

Structure

electron microscopy · 8 distinct chains · 39% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Trafficking protein particle complex subunit	protein	165	46% helix, 15% strand	Q9VSY8
B	GEO08327P1	protein	151	30% helix, 7% strand	Q9VF82
C	Trafficking protein particle complex subunit	protein	145	34% helix, 19% strand	Q9VA95
D	Trafficking protein particle complex subunit	protein	219	24% helix, 27% strand	Q9VLI9
E	Probable trafficking protein particle complex subunit 2	protein	139	45% helix, 17% strand	Q9VUZ1
F	Trafficking protein particle complex subunit 5	protein	164	52% helix, 13% strand	Q7K2Q8
G	Trafficking protein particle complex subunit	protein	169	47% helix, 15% strand	Q9VSY8
H	TRAPPC2L	protein	138	35% helix, 20% strand	A1Z8I0

Pockets

20 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	277	0.82	0.93	56	empty
2	384	0.80	0.89	78	empty
3	97	0.78	0.98	26	empty
4	114	0.78	0.97	34	empty
5	160	0.76	0.93	30	empty

Interfaces

13 interfaces between chains.

C–D · 1779 Å² buried · 42 hydrogen bonds · protein-protein
F–G · 1366 Å² buried · 23 hydrogen bonds · protein-protein
A–B · 1268 Å² buried · 7 hydrogen bonds · protein-protein
B–H · 1155 Å² buried · 24 hydrogen bonds · protein-protein
D–G · 997 Å² buried · 12 hydrogen bonds · protein-protein

Compared structures

7B6X · TRAPPCore from the MiniTRAPPIII complex · the same entry in another collection · chain H against H, TM-score 1.00
Q9VUZ1 · AlphaFold monomer V2.0 prediction for probable trafficking protein particle complex… · a predicted model of the same protein · chain E against A, TM-score 0.92

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9VSY8
Every structure of UniProt Q9VF82
Every structure of UniProt Q9VA95
Every structure of UniProt Q9VLI9
Every structure of UniProt Q9VUZ1
Every structure of UniProt Q7K2Q8
Every structure of UniProt A1Z8I0
Elsewhere: RCSB PDB 7B6X · PDBe 7B6X · UniProt Q9VSY8 · UniProt Q9VF82 · UniProt Q9VA95 · UniProt Q9VLI9 · UniProt Q9VUZ1 · UniProt Q7K2Q8 · UniProt A1Z8I0

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