MolNFT v1 · #173527 · protein
Crystal structure of nhl domain of TRIM2
7B2R · Tripartite motif-containing protein 2: “Crystal structure of nhl domain of TRIM2”. X-ray diffraction, 4 pockets (best druggability 0.75). MolNFT v1 #173527 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7B2R
- Type
- protein
- Length
- 549 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tripartite motif-containing protein 2
- EC
- 2.3.2.27
- UniProt
- Q9C040
- Pockets
- 4 · best druggability 0.75
Structure
x-ray diffraction · 2 distinct chains · 2% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tripartite motif-containing protein 2 (EC 2.3.2.27) | protein | 276 | 2% helix, 49% strand | Q9C040 |
| B | Tripartite motif-containing protein 2 (EC 2.3.2.27) | protein | 273 | 2% helix, 49% strand | Q9C040 |
Ligands and binding sites
- EDO · 1,2-ethanediol · additive · 9 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 748 | 0.75 | 0.80 | 80 | EDO |
| 2 | 402 | 0.69 | 0.81 | 43 | EDO |
| 3 | 419 | 0.69 | 0.81 | 42 | EDO |
| 4 | 335 | 0.69 | 0.82 | 34 | empty |
Interfaces
1 interface between chains.
- A–B · 745 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9C040
- Elsewhere: RCSB PDB 7B2R · PDBe 7B2R · UniProt Q9C040
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