MolNFT v1 · #17340 · protein
Crystal structure of the R124A mutant of the N-lobe human transferrin
1OQH · Serotransferrin: “Crystal structure of the R124A mutant of the N-lobe human transferrin”. X-ray diffraction, 3 ligands (FE, K, CO3), 3 pockets (best druggability 0.78). MolNFT v1 #17340 on GenesisL1: 3D structure, binding sites and…
- PDB
- 1OQH
- Type
- protein
- Length
- 329 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Serotransferrin
- UniProt
- P02787
- Ligands
- FE, K, CO3
- Pockets
- 3 · best druggability 0.78
Structure
x-ray diffraction · 1 distinct chain · 35% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Serotransferrin | protein | 329 | 35% helix, 20% strand | P02787 |
Ligands and binding sites
- FE · Fe (III) ion · metal · chains A
- K · Potassium ion · metal · chains A
- CO3 · Carbonate ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 299 | 0.78 | 0.89 | 44 | CO3 |
| 2 | 56 | 0.39 | 0.81 | 13 | empty |
| 3 | 87 | 0.36 | 0.75 | 16 | empty |
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02787
- Elsewhere: RCSB PDB 1OQH · PDBe 1OQH · UniProt P02787
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