MolNFT v1 · #173379 · protein
Crystal structure of BRD4(1) bound to the dual bet-hdac inhibitor LSH24
7AXR: “Crystal structure of BRD4(1) bound to the dual bet-hdac inhibitor LSH24”. X-ray diffraction, 1 ligand (S7T). MolNFT v1 #173379 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7AXR
- Type
- protein
- Length
- 127 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- O60885
- Ligands
- S7T
Structure
x-ray diffraction · 1 distinct chain.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 127 | — | O60885 |
Ligands and binding sites
- S7T · 4-acetyl-3-ethyl-N-(3-(3-(hydroxyamino)-3-oxopropyl) phenyl)-5-methyl-1H-pyrrole-2-carboxamide · ligand · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7AXR · Crystal structure of BRD4(1) bound to the dual BET-HDAC inhibitor LSH24 · the same entry in another collection · chain A against A, TM-score 1.00
- O60885 · AlphaFold monomer V2.0 prediction for bromodomain-containing protein 4 (O60885) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O60885
- Elsewhere: RCSB PDB 7AXR · PDBe 7AXR · UniProt O60885
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