MolNFT v1 · #173320 · protein

Mertk kinase domain in complex with purine inhibitor

7AW0: “Mertk kinase domain in complex with purine inhibitor”. X-ray diffraction, 1 ligand (S4Q). MolNFT v1 #173320 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7AW0
Type: protein
Length: 269 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: Q12866
Ligands: S4Q

Structure

x-ray diffraction · 1 distinct chain.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	269	—	Q12866

Ligands and binding sites

S4Q · 2-(cyclopentyloxy)-9-(2,6-difluorobenzyl)-N-methyl-9H-purin-6-amine · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

7AW0 · MerTK kinase domain in complex with purine inhibitor · the same entry in another collection · chain A against A, TM-score 1.00
Q12866 · AlphaFold monomer V2.0 prediction for tyrosine-protein kinase mer (Q12866) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q12866
Elsewhere: RCSB PDB 7AW0 · PDBe 7AW0 · UniProt Q12866

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