MolNFT v1 · #173205 · protein + RNA
Bacillus subtilis ribosome-associated quality control complex state B, multibody refinement focussed on rqch. ribosomal 50S subunit with P- tRNA, rqch, and RQCP/YABO
7ASA · RQC2 homolog rqch: “Bacillus subtilis ribosome-associated quality control complex state B, multibody refinement focussed on rqch.…”. Electron microscopy, 14 pockets (best druggability 0.80). MolNFT v1 #173205 on GenesisL1: 3D…
- PDB
- 7ASA
- Type
- protein + RNA
- Length
- 866 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RQC2 homolog rqch; Uncharacterized protein yabo; TRNA-ala-1-1; 23S rRNA; 50S ribosomal…
- UniProt
- O34693, P37557, Q06796
- Pockets
- 14 · best druggability 0.80
Structure
electron microscopy · 5 distinct chains · 38% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| 0 | RQC2 homolog rqch | protein | 536 | 38% helix, 23% strand | O34693 |
| 1 | Uncharacterized protein yabo | protein | 83 | 27% helix, 33% strand | P37557 |
| 2 | TRNA-ala-1-1 | rna | 34 | — | — |
| A | 23S rRNA | rna | 82 | — | — |
| K | 50S ribosomal protein L11 | protein | 131 | 44% helix, 18% strand | Q06796 |
Pockets
14 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1056 | 0.80 | 0.82 | 81 | empty |
| 2 | 916 | 0.75 | 0.79 | 70 | empty |
| 3 | 397 | 0.69 | 0.81 | 45 | empty |
| 4 | 428 | 0.67 | 0.80 | 55 | empty |
| 5 | 348 | 0.63 | 0.79 | 49 | empty |
Interfaces
8 interfaces between chains.
- 0–2 · 1401 Ų buried · 36 hydrogen bonds · protein-nucleic
- A–K · 1129 Ų buried · 31 hydrogen bonds · protein-nucleic
- 0–1 · 636 Ų buried · 6 hydrogen bonds · protein-protein
- 0–A · 514 Ų buried · 13 hydrogen bonds · protein-nucleic
- 1–2 · 329 Ų buried · 6 hydrogen bonds · protein-nucleic
Compared structures
- 7ASA · Bacillus subtilis ribosome-associated quality control complex state B, multibody… · the same entry in another collection · chain K against K, TM-score 1.00
- P37557 · AlphaFold monomer V2.0 prediction for uncharacterized protein yabo (P37557) · a predicted model of the same protein · chain 1 against A, TM-score 0.97
- Q06796 · AlphaFold monomer V2.0 prediction for 50S ribosomal protein L11 (Q06796) · a predicted model of the same protein · chain K against A, TM-score 0.94
- O34693 · AlphaFold monomer V2.0 prediction for RQC2 homolog rqch (O34693) · a predicted model of the same protein · chain 0 against A, TM-score 0.69
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O34693
- Every structure of UniProt P37557
- Every structure of UniProt Q06796
- Elsewhere: RCSB PDB 7ASA · PDBe 7ASA · UniProt O34693 · UniProt P37557 · UniProt Q06796
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