MolNFT v1 · #173165 · protein
Flavin-dependent tryptophan halogenase thal: N-terminally his-tagged form of quintuple mutant (nhis-thal-REBH5)
7AQV · Tryptophan 6-halogenase: “Flavin-dependent tryptophan halogenase thal: N-terminally his-tagged form of quintuple mutant…”. X-ray diffraction, 10 pockets (best druggability 0.79). MolNFT v1 #173165 on GenesisL1: 3D structure, binding…
- PDB
- 7AQV
- Type
- protein
- Length
- 1,050 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tryptophan 6-halogenase
- UniProt
- A1E280
- Pockets
- 10 · best druggability 0.79
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tryptophan 6-halogenase | protein | 520 | 40% helix, 21% strand | A1E280 |
| B | Tryptophan 6-halogenase | protein | 530 | 40% helix, 21% strand | A1E280 |
Ligands and binding sites
- GOL · Glycerol · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 664 | 0.79 | 0.84 | 79 | empty |
| 2 | 819 | 0.76 | 0.80 | 60 | GOL |
| 3 | 806 | 0.74 | 0.79 | 63 | empty |
| 4 | 367 | 0.72 | 0.84 | 40 | empty |
| 5 | 604 | 0.71 | 0.79 | 63 | GOL |
Interfaces
1 interface between chains.
- A–B · 2156 Ų buried · 37 hydrogen bonds · protein-protein
Compared structures
- 7AQV · Flavin-dependent tryptophan halogenase Thal: N-terminally His-tagged form of quintuple… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A1E280
- Elsewhere: RCSB PDB 7AQV · PDBe 7AQV · UniProt A1E280
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.