The FK1 domain of FKBP51 in complex with (1S,5S,6R)-10- (BENZO[D]THIAZOL-6-ylsulfonyl)-5-(methoxymethyl)-3-(pyridin-2- ylmethyl)-3,10-DIAZABICYCLO[4.3.1]DECAN-2-one

Structure

x-ray diffraction · 1 distinct chain · 16% helix, 36% strand (DSSP).

Ligands and binding sites

• RQW · (1~{S},5~{S},6~{R})-10-(1,3-benzothiazol-6-ylsulfonyl)-5-(methoxymethyl)-3-(pyridin-2-ylmethyl)-3,10-diazabicyclo[4.3.1]decan-2-one · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Compared structures

• 7APQ · The Fk1 domain of FKBP51 in complex with (1S,5S,6R)-10-(benzo[d]thiazol-6-ylsulfonyl)-5-(m… · the same entry in another collection · chain A against A, TM-score 1.00
• Q13451 · AlphaFold monomer V2.0 prediction for peptidyl-prolyl cis-trans isomerase FKBP5 (Q13451) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q13451
• Elsewhere: RCSB PDB 7APQ · PDBe 7APQ · UniProt Q13451