MolNFT v1 · #173102 · protein

Crystal structure of a TRPM2 domain

7AOV · Transient receptor potential cation channel subfamily M…: “Crystal structure of a TRPM2 domain”. X-ray diffraction, 1 ligand (ZN), 8 pockets (best druggability 0.76). MolNFT v1 #173102 on GenesisL1: 3D structure, binding sites and…

PDB: 7AOV
Type: protein
Length: 754 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transient receptor potential cation channel subfamily M member 2
UniProt: A0A0R4IMY7
Ligands: ZN
Pockets: 8 · best druggability 0.76

Structure

x-ray diffraction · 1 distinct chain · 40% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Transient receptor potential cation channel subfamily M member 2	protein	377	40% helix, 20% strand	A0A0R4IMY7

Ligands and binding sites

ZN · Zinc ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1051	0.76	0.79	92	empty
2	506	0.67	0.78	71	empty
3	398	0.63	0.78	53	empty
4	278	0.63	0.81	46	empty
5	72	0.40	0.79	16	empty

Interfaces

1 interface between chains.

A–B · 1289 Å² buried · 18 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 16 modified (engineered).

Compared structures

7AOV · Crystal Structure of a TRPM2 Domain · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A0R4IMY7
Elsewhere: RCSB PDB 7AOV · PDBe 7AOV · UniProt A0A0R4IMY7

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