MolNFT v1 · #173074 · protein

Structure of the candida albicans gamma-tubulin small complex

7ANZ · Tubulin gamma chain: “Structure of the candida albicans gamma-tubulin small complex”. Electron microscopy, 20 pockets (best druggability 0.74). MolNFT v1 #173074 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7ANZ
Type: protein
Length: 2,041 residues
Chains: 4
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tubulin gamma chain; Spindle pole body component
UniProt: O93807, Q59PZ2, A0A1D8PS42
Pockets: 20 · best druggability 0.74

Structure

electron microscopy · 4 distinct chains · 53% helix, 7% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	Tubulin gamma chain	protein	410	38% helix, 15% strand	O93807
A	Tubulin gamma chain	protein	400	45% helix, 16% strand	O93807
C	Spindle pole body component	protein	618	61% helix, 1% strand	Q59PZ2
D	Spindle pole body component	protein	613	59% helix, 2% strand	A0A1D8PS42

Pockets

20 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	602	0.74	0.81	53	empty
2	53	0.70	0.98	24	empty
3	129	0.67	0.89	26	empty
4	504	0.66	0.78	45	empty
5	354	0.66	0.81	37	empty

Interfaces

4 interfaces between chains.

B–D · 3150 Å² buried · 27 hydrogen bonds · protein-protein
A–C · 2503 Å² buried · 27 hydrogen bonds · protein-protein
C–D · 2000 Å² buried · 17 hydrogen bonds · protein-protein
B–C · 124 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

7ANZ · Structure of the Candida albicans gamma-Tubulin Small Complex · the same entry in another collection · chain B against B, TM-score 1.00
O93807 · AlphaFold monomer V2.0 prediction for tubulin gamma chain (O93807) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O93807
Every structure of UniProt Q59PZ2
Every structure of UniProt A0A1D8PS42
Elsewhere: RCSB PDB 7ANZ · PDBe 7ANZ · UniProt O93807 · UniProt Q59PZ2 · UniProt A0A1D8PS42

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