MolNFT v1 · #173062 · protein
Mlghc, GDP-mannoheptose C4 reductase from campylobacter jejuni with NADP bound
7ANC · GDP-L-fucose synthase: “Mlghc, GDP-mannoheptose C4 reductase from campylobacter jejuni with NADP bound”. X-ray diffraction, 1 ligand (NAP), 3 pockets (best druggability 0.75). MolNFT v1 #173062 on GenesisL1: 3D structure, binding…
- PDB
- 7ANC
- Type
- protein
- Length
- 650 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- GDP-L-fucose synthase
- EC
- 1.1.1.271
- UniProt
- A0A2U0QM62
- Ligands
- NAP
- Pockets
- 3 · best druggability 0.75
Structure
x-ray diffraction · 2 distinct chains · 44% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | GDP-L-fucose synthase (EC 1.1.1.271) | protein | 336 | 46% helix, 15% strand | A0A2U0QM62 |
| B | GDP-L-fucose synthase (EC 1.1.1.271) | protein | 314 | 43% helix, 15% strand | A0A2U0QM62 |
Ligands and binding sites
- NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 713 | 0.75 | 0.80 | 66 | NAP |
| 2 | 729 | 0.71 | 0.78 | 70 | NAP |
| 3 | 63 | 0.29 | 0.75 | 11 | empty |
Interfaces
1 interface between chains.
- A–B · 1873 Ų buried · 30 hydrogen bonds · protein-protein
Compared structures
- 7ANC · MlghC, GDP-mannoheptose C4 reductase from Campylobacter jejuni with NADP bound · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A2U0QM62
- Elsewhere: RCSB PDB 7ANC · PDBe 7ANC · UniProt A0A2U0QM62
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