MolNFT v1 · #173023 · protein
Crystal structure of NLRP3 nacht domain in complex with a potent inhibitor
7ALV: “Crystal structure of NLRP3 nacht domain in complex with a potent inhibitor”. X-ray diffraction, 2 ligands (RM5, ADP). MolNFT v1 #173023 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7ALV
- Type
- protein
- Length
- 472 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q96P20
- Ligands
- RM5, ADP
Structure
x-ray diffraction · 1 distinct chain.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 472 | — | Q96P20 |
Ligands and binding sites
- RM5 · 1-[4-chloranyl-2,6-di(propan-2-yl)phenyl]-3-[4-(2-oxidanylpropan-2-yl)furan-2-yl]sulfonyl-urea · ligand · chains A
- ADP · Adenosine-5'-diphosphate · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7ALV · Crystal Structure of NLRP3 NACHT domain in complex with a potent inhibitor · the same entry in another collection · chain A against A, TM-score 1.00
- Q96P20 · AlphaFold monomer V2.0 prediction for nacht, lrr and pyd domains- containing protein 3… · a predicted model of the same protein · chain A against A, TM-score 0.64
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96P20
- Elsewhere: RCSB PDB 7ALV · PDBe 7ALV · UniProt Q96P20
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