Crystal structure of CHK1 kinase domain in complex with a claspin phosphopeptide

Structure

x-ray diffraction · 4 distinct chains.

Ligands and binding sites

• STU · Staurosporine · ligand · 2 copies · chains A, B
• ZN · Zinc ion · metal · chains A, C
• EDO · 1,2-ethanediol · additive · 7 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 7AKO · Crystal structure of CHK1 kinase domain in complex with a CLASPIN phosphopeptide · the same entry in another collection · chain A against A, TM-score 1.00
• O14757 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase CHK1 (O14757) · a predicted model of the same protein · chain B against A, TM-score 0.96
• 2C3K · Identification of a buried pocket for potent and selective inhibition of CHK1: prediction… · a predicted model of the same protein · chain B against A, TM-score 0.95
• 2C3L · Identification of a buried pocket for potent and selective inhibition of CHK1: prediction… · a predicted model of the same protein · chain B against A, TM-score 0.94
• 2C3J · Identification of a buried pocket for potent and selective inhibition of CHK1: prediction… · a predicted model of the same protein · chain B against A, TM-score 0.94

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt O14757
• Every structure of UniProt Q9HAW4
• Elsewhere: RCSB PDB 7AKO · PDBe 7AKO · UniProt O14757 · UniProt Q9HAW4