MolNFT v1 · #172944 · protein
LN02 FAB
7AJ6: “LN02 FAB”. X-ray diffraction, 4 pockets (best druggability 0.58). MolNFT v1 #172944 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7AJ6
- Type
- protein
- Length
- 431 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- LN02; LN02 heavy chain
- Pockets
- 4 · best druggability 0.58
Structure
x-ray diffraction · 2 distinct chains · 7% helix, 52% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | LN02 | protein | 209 | 7% helix, 52% strand | — |
| H | LN02 heavy chain | protein | 222 | 7% helix, 53% strand | — |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 445 | 0.58 | 0.74 | 57 | empty |
| 2 | 78 | 0.39 | 0.78 | 17 | empty |
| 3 | 53 | 0.28 | 0.75 | 18 | empty |
| 4 | 50 | 0.27 | 0.75 | 17 | empty |
Interfaces
1 interface between chains.
- L–H · 1847 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 7AJ6 · LN02 Fab · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 7AJ6 · PDBe 7AJ6
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