MolNFT v1 · #172920 · protein
Crystal structure of a truncated form of the KLC1-tpr domain ([A1-B5] fragment) - monoclinic crystal form
7AIE · Kinesin light chain 1: “Crystal structure of a truncated form of the KLC1-tpr domain ([A1-B5] fragment) - monoclinic crystal form”. X-ray diffraction, 1 ligand (MG), 6 pockets (best druggability 0.35). MolNFT v1 #172920 on…
- PDB
- 7AIE
- Type
- protein
- Length
- 827 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Kinesin light chain 1
- UniProt
- Q07866
- Ligands
- MG
- Pockets
- 6 · best druggability 0.35
Structure
x-ray diffraction · 3 distinct chains · 82% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Kinesin light chain 1 | protein | 207 | 82% helix, 0% strand | Q07866 |
| B | Kinesin light chain 1 | protein | 208 | 82% helix, 0% strand | Q07866 |
| D | Kinesin light chain 1 | protein | 205 | 83% helix, 0% strand | Q07866 |
Ligands and binding sites
- MG · Magnesium ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 73 | 0.35 | 0.77 | 17 | empty |
| 2 | 79 | 0.34 | 0.75 | 21 | empty |
| 3 | 55 | 0.31 | 0.76 | 19 | empty |
| 4 | 52 | 0.29 | 0.75 | 14 | empty |
| 5 | 52 | 0.29 | 0.76 | 15 | empty |
Interfaces
3 interfaces between chains.
- A–C · 681 Ų buried · 2 hydrogen bonds · protein-protein
- B–D · 646 Ų buried · 4 hydrogen bonds · protein-protein
- A–B · 534 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 7AIE · Crystal structure of a truncated form of the KLC1-TPR domain ([A1-B5] fragment)… · the same entry in another collection · chain A against A, TM-score 1.00
- Q07866 · AlphaFold monomer V2.0 prediction for kinesin light chain 1 (Q07866) · a predicted model of the same protein · chain D against A, TM-score 0.83
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q07866
- Elsewhere: RCSB PDB 7AIE · PDBe 7AIE · UniProt Q07866
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