MolNFT v1 · #17279 · protein

Crystal structure of A1PI-pittsburgh in the native conformation

1OO8 · Alpha-1-antitrypsin precursor: “Crystal structure of A1PI-pittsburgh in the native conformation”. X-ray diffraction, 2 pockets (best druggability 0.32). MolNFT v1 #17279 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1OO8
Type: protein
Length: 370 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Alpha-1-antitrypsin precursor
UniProt: P01009
Pockets: 2 · best druggability 0.32

Structure

x-ray diffraction · 1 distinct chain · 29% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Alpha-1-antitrypsin precursor	protein	370	29% helix, 31% strand	P01009

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	71	0.32	0.75	16	empty
2	64	0.26	0.72	16	empty

Compared structures

1OO8 · Crystal structure of A1PI-pittsburgh in the native conformation · the same entry in another collection · chain A against A, TM-score 1.00
P01009 · AlphaFold monomer V2.0 prediction for alpha-1-antitrypsin (P01009) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01009
Elsewhere: RCSB PDB 1OO8 · PDBe 1OO8 · UniProt P01009

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