MolNFT v1 · #172779 · protein

Crystal structure of helicase PIF1 from thermus oshimai mutant Q164C- E409C

7ADA · PIF1 helicase: “Crystal structure of helicase PIF1 from thermus oshimai mutant Q164C- E409C”. X-ray diffraction, 11 pockets (best druggability 0.83). MolNFT v1 #172779 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7ADA
Type: protein
Length: 872 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: PIF1 helicase
UniProt: K7RJ88
Pockets: 11 · best druggability 0.83

Structure

x-ray diffraction · 1 distinct chain · 31% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	PIF1 helicase	protein	436	31% helix, 21% strand	K7RJ88

Pockets

11 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	937	0.83	0.84	97	empty
2	579	0.81	0.87	67	empty
3	409	0.73	0.83	45	empty
4	212	0.67	0.85	35	empty
5	121	0.53	0.82	19	empty

Interfaces

1 interface between chains.

A–B · 123 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

7ADA · Crystal structure of helicase Pif1 from Thermus oshimai mutant Q164C-E409C · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt K7RJ88
Elsewhere: RCSB PDB 7ADA · PDBe 7ADA · UniProt K7RJ88

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.