MolNFT v1 · #172769 · protein
RDELTAD2 H/L (lmw SLP/HMW slp) complex from C. difficile slpa (R20291 strain)
7ACZ · Slpl DELTAD2 (lmw slp D2 TRUNCATION),SLPL DELTAD2 (lmw slp…: “RDELTAD2 H/L (lmw SLP/HMW slp) complex from C. difficile slpa (R20291 strain)”. X-ray diffraction, 14 pockets (best druggability 0.67). MolNFT v1 #172769 on GenesisL1: 3D…
- PDB
- 7ACZ
- Type
- protein
- Length
- 1,109 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Slpl DELTAD2 (lmw slp D2 TRUNCATION),SLPL DELTAD2 (lmw slp D2 truncation); Slph (hmw slp)
- UniProt
- C9YQ17
- Pockets
- 14 · best druggability 0.67
Structure
x-ray diffraction · 4 distinct chains · 36% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Slpl DELTAD2 (lmw slp D2 TRUNCATION),SLPL DELTAD2 (lmw slp D2 truncation) | protein | 153 | 33% helix, 32% strand | C9YQ17 |
| B | Slph (hmw slp) | protein | 405 | 36% helix, 17% strand | C9YQ17 |
| C | Slpl DELTAD2 (lmw slp D2 TRUNCATION),SLPL DELTAD2 (lmw slp D2 truncation) | protein | 146 | 34% helix, 32% strand | C9YQ17 |
| D | Slph (hmw slp) | protein | 405 | 37% helix, 17% strand | C9YQ17 |
Pockets
14 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 55 | 0.67 | 0.96 | 22 | empty |
| 2 | 546 | 0.65 | 0.77 | 68 | empty |
| 3 | 256 | 0.57 | 0.77 | 42 | empty |
| 4 | 194 | 0.47 | 0.75 | 26 | empty |
| 5 | 114 | 0.44 | 0.78 | 25 | empty |
Interfaces
5 interfaces between chains.
- A–B · 2412 Ų buried · 34 hydrogen bonds · protein-protein
- C–D · 2158 Ų buried · 30 hydrogen bonds · protein-protein
- B–D · 523 Ų buried · 6 hydrogen bonds · protein-protein
- B–C · 387 Ų buried · 4 hydrogen bonds · protein-protein
- A–D · 380 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 7ACZ · RdeltaD2 H/L (LMW SLP/HMW SLP) complex from C. difficile SlpA (R20291 strain) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt C9YQ17
- Elsewhere: RCSB PDB 7ACZ · PDBe 7ACZ · UniProt C9YQ17
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