MolNFT v1 · #172644 · protein
Complex of rice blast (magnaporthe oryzae) effector protein avr-pikc with the hma domain of pikh-1 from rice (oryza sativa)
7A8X · Nbs-lrr class disease resistance protein: “Complex of rice blast (magnaporthe oryzae) effector protein avr-pikc with the hma domain of pikh-1 from rice…”. X-ray diffraction, 4 pockets (best druggability 0.47). MolNFT v1 #172644 on…
- PDB
- 7A8X
- Type
- protein
- Length
- 453 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nbs-lrr class disease resistance protein; Avr-pik protein
- UniProt
- D5L9G5, G4MXW3
- Pockets
- 4 · best druggability 0.47
Structure
x-ray diffraction · 5 distinct chains · 17% helix, 42% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nbs-lrr class disease resistance protein | protein | 72 | 29% helix, 38% strand | D5L9G5 |
| B, E | Nbs-lrr class disease resistance protein | protein | 74 | 28% helix, 38% strand | D5L9G5 |
| C | Avr-pik protein | protein | 80 | 0% helix, 48% strand | G4MXW3 |
| D | Nbs-lrr class disease resistance protein | protein | 71 | 30% helix, 41% strand | D5L9G5 |
| F | Avr-pik protein | protein | 82 | 4% helix, 46% strand | G4MXW3 |
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 208 | 0.47 | 0.74 | 31 | empty |
| 2 | 58 | 0.34 | 0.77 | 16 | empty |
| 3 | 68 | 0.32 | 0.75 | 17 | empty |
| 4 | 60 | 0.30 | 0.75 | 14 | empty |
Interfaces
8 interfaces between chains.
- E–F · 1075 Ų buried · 18 hydrogen bonds · protein-protein
- B–C · 1045 Ų buried · 14 hydrogen bonds · protein-protein
- D–E · 521 Ų buried · 10 hydrogen bonds · protein-protein
- A–B · 510 Ų buried · 9 hydrogen bonds · protein-protein
- A–F · 374 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 7A8X · Complex of rice blast (Magnaporthe oryzae) effector protein AVR-PikC with the HMA domain… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt D5L9G5
- Every structure of UniProt G4MXW3
- Elsewhere: RCSB PDB 7A8X · PDBe 7A8X · UniProt D5L9G5 · UniProt G4MXW3
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