MolNFT v1 · #172499 · protein
Crystal structure of the aph coiled-coil in complex with NB49
7A48 · Nanobody 49: “Crystal structure of the aph coiled-coil in complex with NB49”. X-ray diffraction, 2 ligands (ACE, NH2), 1 pocket (best druggability 0.38). MolNFT v1 #172499 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 7A48
- Type
- protein
- Length
- 160 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nanobody 49; Aph colied-coil
- Ligands
- ACE, NH2
- Pockets
- 1 · best druggability 0.38
Structure
x-ray diffraction · 2 distinct chains · 28% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nanobody 49 | protein | 120 | 5% helix, 52% strand | — |
| B | Aph colied-coil | protein | 40 | 95% helix, 0% strand | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 119 | 0.38 | 0.75 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 844 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 covalent, 1 disulfide (covalent ligand, disulfide).
Compared structures
- 7A48 · Crystal structure of the APH coiled-coil in complex with Nb49 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 7A48 · PDBe 7A48
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.