MolNFT v1 · #172497 · protein

Small conductance mechanosensitive channel ybio

7A46 · Putative transport protein: “Small conductance mechanosensitive channel ybio”. Electron microscopy, 20 pockets (best druggability 0.71). MolNFT v1 #172497 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7A46
Type: protein
Length: 1,561 residues
Chains: 7
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Putative transport protein
UniProt: J7R2E5
Pockets: 20 · best druggability 0.71

Structure

electron microscopy · 1 distinct chain · 46% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F, G	Putative transport protein	protein	223	46% helix, 26% strand	J7R2E5

Pockets

20 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	685	0.71	0.77	96	empty
2	382	0.64	0.78	56	empty
3	351	0.61	0.77	54	empty
4	327	0.55	0.74	42	empty
5	182	0.53	0.78	19	empty

Interfaces

14 interfaces between chains.

E–F · 2126 Å² buried · 16 hydrogen bonds · protein-protein
A–G · 2121 Å² buried · 17 hydrogen bonds · protein-protein
A–B · 2111 Å² buried · 16 hydrogen bonds · protein-protein
B–C · 2109 Å² buried · 15 hydrogen bonds · protein-protein
F–G · 2076 Å² buried · 15 hydrogen bonds · protein-protein

Compared structures

7A46 · small conductance mechanosensitive channel YbiO · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt J7R2E5
Elsewhere: RCSB PDB 7A46 · PDBe 7A46 · UniProt J7R2E5

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