MolNFT v1 · #172491 · protein
Nucleotide-free osm-3 kinesin motor domain
7A40 · Osmotic avoidance abnormal protein 3: “Nucleotide-free osm-3 kinesin motor domain”. X-ray diffraction, 1 ligand (SO4), 8 pockets (best druggability 0.70). MolNFT v1 #172491 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 7A40
- Type
- protein
- Length
- 628 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Osmotic avoidance abnormal protein 3
- UniProt
- P46873
- Ligands
- SO4
- Pockets
- 8 · best druggability 0.70
Structure
x-ray diffraction · 2 distinct chains · 32% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Osmotic avoidance abnormal protein 3 | protein | 313 | 33% helix, 30% strand | P46873 |
| B | Osmotic avoidance abnormal protein 3 | protein | 315 | 31% helix, 30% strand | P46873 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 672 | 0.70 | 0.77 | 61 | GOL |
| 2 | 146 | 0.56 | 0.82 | 24 | empty |
| 3 | 147 | 0.55 | 0.81 | 22 | empty |
| 4 | 217 | 0.54 | 0.78 | 41 | SO4 |
| 5 | 70 | 0.37 | 0.78 | 19 | SO4 |
Interfaces
1 interface between chains.
- A–B · 443 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P46873
- Elsewhere: RCSB PDB 7A40 · PDBe 7A40 · UniProt P46873
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.