MolNFT v1 · #172338 · protein

MB_CRS6-13 bound to crsas-6_N

6ZZD · Centriole protein: “MB_CRS6-13 bound to crsas-6_N”. X-ray diffraction, 4 pockets (best druggability 0.77). MolNFT v1 #172338 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6ZZD
Type: protein
Length: 492 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Centriole protein; MB_CRS6-13
UniProt: A9CQL4
Pockets: 4 · best druggability 0.77

Structure

x-ray diffraction · 4 distinct chains · 13% helix, 49% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Centriole protein	protein	147	16% helix, 48% strand	A9CQL4
B	Centriole protein	protein	147	18% helix, 51% strand	A9CQL4
C	MB_CRS6-13	protein	102	7% helix, 46% strand	—
D	MB_CRS6-13	protein	96	6% helix, 51% strand	—

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1053	0.77	0.79	104	empty
2	71	0.44	0.81	23	empty
3	146	0.41	0.74	24	empty
4	131	0.40	0.74	24	empty

Interfaces

5 interfaces between chains.

A–B · 531 Å² buried · 5 hydrogen bonds · protein-protein
A–D · 527 Å² buried · 8 hydrogen bonds · protein-protein
B–C · 508 Å² buried · 3 hydrogen bonds · protein-protein
A–C · 178 Å² buried · 1 hydrogen bond · protein-protein
B–D · 13 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

6ZZD · MB_CRS6-13 bound to CrSAS-6_N · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A9CQL4
Elsewhere: RCSB PDB 6ZZD · PDBe 6ZZD · UniProt A9CQL4

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.