MolNFT v1 · #172323 · protein

Structure of a plasmodium pir protein ectodomain

6ZYV · Cir protein: “Structure of a plasmodium pir protein ectodomain”. X-ray diffraction, 11 pockets (best druggability 0.79). MolNFT v1 #172323 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6ZYV
Type: protein
Length: 694 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cir protein
UniProt: A0A077TLQ4
Pockets: 11 · best druggability 0.79

Structure

x-ray diffraction · 3 distinct chains · 64% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cir protein	protein	238	63% helix, 1% strand	A0A077TLQ4
B	Cir protein	protein	236	64% helix, 0% strand	A0A077TLQ4
C	Cir protein	protein	220	66% helix, 1% strand	A0A077TLQ4

Pockets

11 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1160	0.79	0.80	93	empty
2	99	0.58	0.86	25	empty
3	142	0.48	0.78	22	empty
4	88	0.47	0.81	16	empty
5	105	0.46	0.79	23	empty

Interfaces

3 interfaces between chains.

A–B · 844 Å² buried · 11 hydrogen bonds · protein-protein
A–C · 572 Å² buried · 5 hydrogen bonds · protein-protein
B–C · 427 Å² buried · 5 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 14 disulfide (disulfide).

Compared structures

6ZYV · Structure of a Plasmodium PIR protein ectodomain · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A077TLQ4
Elsewhere: RCSB PDB 6ZYV · PDBe 6ZYV · UniProt A0A077TLQ4

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