MolNFT v1 · #172171 · protein
Assembly intermediates of orthoreovirus captured in the cell
6ZTY · Outer capsid protein mu-1: “Assembly intermediates of orthoreovirus captured in the cell”. Electron microscopy, 20 pockets (best druggability 0.92). MolNFT v1 #172171 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6ZTY
- Type
- protein
- Length
- 3,018 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Outer capsid protein mu-1; Outer capsid protein sigma-3
- UniProt
- P11077, P07939
- Pockets
- 20 · best druggability 0.92
Structure
electron microscopy · 2 distinct chains · 37% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H, I, J | Outer capsid protein mu-1 | protein | 641 | 36% helix, 18% strand | P11077 |
| U, V, W | Outer capsid protein sigma-3 | protein | 365 | 40% helix, 12% strand | P07939 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1017 | 0.92 | 0.94 | 169 | empty |
| 2 | 1034 | 0.91 | 0.93 | 181 | empty |
| 3 | 951 | 0.90 | 0.92 | 145 | empty |
| 4 | 1079 | 0.89 | 0.91 | 143 | empty |
| 5 | 648 | 0.89 | 0.94 | 112 | empty |
Interfaces
9 interfaces between chains.
- I–J · 4135 Ų buried · 44 hydrogen bonds · protein-protein
- H–J · 3961 Ų buried · 36 hydrogen bonds · protein-protein
- H–I · 3901 Ų buried · 44 hydrogen bonds · protein-protein
- H–U · 1209 Ų buried · 23 hydrogen bonds · protein-protein
- I–W · 1177 Ų buried · 27 hydrogen bonds · protein-protein
Compared structures
- 6ZTY · Assembly intermediates of orthoreovirus captured in the cell · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P11077
- Every structure of UniProt P07939
- Elsewhere: RCSB PDB 6ZTY · PDBe 6ZTY · UniProt P11077 · UniProt P07939
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