MolNFT v1 · #172157 · protein

Crystal structure of the BCR Fab fragment from subset #169 case P6540

6ZTD · Heavy chain of the Fab fragment from BCR derived from the…: “Crystal structure of the BCR Fab fragment from subset #169 case P6540”. X-ray diffraction, 4 pockets (best druggability 0.56). MolNFT v1 #172157 on GenesisL1: 3D…

PDB: 6ZTD
Type: protein
Length: 399 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Heavy chain of the Fab fragment from BCR derived from the P6540 cll clone; Light chain of…
Pockets: 4 · best druggability 0.56

Structure

x-ray diffraction · 2 distinct chains · 5% helix, 48% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
H	Heavy chain of the Fab fragment from BCR derived from the P6540 cll clone	protein	187	3% helix, 49% strand	—
L	Light chain of the Fab fragment from BCR derived from the P6540 cll clone	protein	212	7% helix, 47% strand	—

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	412	0.56	0.74	59	empty
2	61	0.30	0.75	13	empty
3	65	0.30	0.74	17	empty
4	50	0.28	0.76	18	empty

Interfaces

1 interface between chains.

H–L · 1808 Å² buried · 17 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

6ZTD · Crystal structure of the BCR Fab fragment from subset #169 case P6540 · the same entry in another collection · chain H against H, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6ZTD · PDBe 6ZTD

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