Crystal structure of angiotensin-1 converting enzyme C-domain with inserted symmetry molecule C-terminus.

Structure

x-ray diffraction · 1 distinct chain · 63% helix, 3% strand (DSSP).

Ligands and binding sites

• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 6 copies · chains A
• BMA · beta-D-mannopyranose · sugar · 2 copies
• MAN · alpha-D-mannopyranose · sugar · 2 copies · chains A
• FUC · alpha-L-fucopyranose · sugar · chains A
• ZN · Zinc ion · metal · chains A
• CL · Chloride ion · ion · 2 copies · chains A
• EDO · 1,2-ethanediol · additive · 3 copies · chains A
• ACT · Acetate ion · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Modifications

Observed in the structure: 3 disulfide, 2 glycan (disulfide, N-glycosylation).

Compared structures

• 6ZPU · Crystal structure of Angiotensin-1 converting enzyme C-domain with inserted symmetry… · the same entry in another collection · chain A against A, TM-score 1.00
• P12821 · AlphaFold monomer V2.0 prediction for angiotensin-converting enzyme (P12821) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P12821
• Elsewhere: RCSB PDB 6ZPU · PDBe 6ZPU · UniProt P12821