MolNFT v1 · #172053 · protein
Kinesin binding protein complexed with KIF15 motor domain
6ZPH · Kif-binding protein: “Kinesin binding protein complexed with KIF15 motor domain”. Electron microscopy, 2 ligands (ADP, MG), 19 pockets (best druggability 0.84). MolNFT v1 #172053 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 6ZPH
- Type
- protein
- Length
- 772 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Kif-binding protein; Kinesin-like protein KIF15
- UniProt
- Q96EK5, Q9NS87
- Ligands
- ADP, MG
- Pockets
- 19 · best druggability 0.84
Structure
electron microscopy · 2 distinct chains · 59% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Kif-binding protein | protein | 457 | 78% helix, 0% strand | Q96EK5 |
| B | Kinesin-like protein KIF15 | protein | 315 | 30% helix, 21% strand | Q9NS87 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
19 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 798 | 0.84 | 0.86 | 104 | empty |
| 2 | 892 | 0.80 | 0.82 | 79 | empty |
| 3 | 405 | 0.80 | 0.88 | 75 | empty |
| 4 | 123 | 0.78 | 0.96 | 29 | empty |
| 5 | 164 | 0.74 | 0.92 | 44 | empty |
Interfaces
1 interface between chains.
- A–B · 1848 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
- 6ZPH · Kinesin binding protein complexed with Kif15 motor domain · the same entry in another collection · chain A against A, TM-score 1.00
- Q96EK5 · AlphaFold monomer V2.0 prediction for kif-binding protein (Q96EK5) · a predicted model of the same protein · chain A against A, TM-score 0.88
- Q9NS87 · AlphaFold monomer V2.0 prediction for kinesin-like protein KIF15 (Q9NS87) · a predicted model of the same protein · chain B against A, TM-score 0.82
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96EK5
- Every structure of UniProt Q9NS87
- Elsewhere: RCSB PDB 6ZPH · PDBe 6ZPH · UniProt Q96EK5 · UniProt Q9NS87
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