MolNFT v1 · #171953 · protein
Open-closed state of the BT1762-BT1763 levan transport system
6ZM1 · Susd homolog: “Open-closed state of the BT1762-BT1763 levan transport system”. Electron microscopy, 20 pockets (best druggability 0.83). MolNFT v1 #171953 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6ZM1
- Type
- protein
- Length
- 2,844 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Susd homolog; Susc homolog
- UniProt
- Q8A6W4, Q8A6W3
- Pockets
- 20 · best druggability 0.83
Structure
electron microscopy · 4 distinct chains · 21% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Susd homolog | protein | 552 | 37% helix, 5% strand | Q8A6W4 |
| B | Susc homolog | protein | 933 | 7% helix, 39% strand | Q8A6W3 |
| C | Susd homolog | protein | 555 | 44% helix, 8% strand | Q8A6W4 |
| D | Susc homolog | protein | 804 | 10% helix, 50% strand | Q8A6W3 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 263 | 0.83 | 0.95 | 38 | empty |
| 2 | 988 | 0.81 | 0.83 | 119 | empty |
| 3 | 169 | 0.81 | 0.96 | 32 | empty |
| 4 | 673 | 0.78 | 0.83 | 108 | empty |
| 5 | 946 | 0.77 | 0.79 | 71 | empty |
Interfaces
6 interfaces between chains.
- C–D · 3952 Ų buried · 72 hydrogen bonds · protein-protein
- A–B · 2774 Ų buried · 34 hydrogen bonds · protein-protein
- B–D · 2358 Ų buried · 9 hydrogen bonds · protein-protein
- B–C · 290 Ų buried · 2 hydrogen bonds · protein-protein
- A–D · 194 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 6ZM1 · Open-closed state of the Bt1762-Bt1763 levan transport system · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8A6W4
- Every structure of UniProt Q8A6W3
- Elsewhere: RCSB PDB 6ZM1 · PDBe 6ZM1 · UniProt Q8A6W4 · UniProt Q8A6W3
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