MolNFT v1 · #17195 · protein
Hexameric replicative DNA helicase repa from plasmid RSF1010 - cubic crystal structure
1OLO · Regulatory protein repa: “Hexameric replicative DNA helicase repa from plasmid RSF1010 - cubic crystal structure”. X-ray diffraction, 1 ligand (SO4), 3 pockets (best druggability 0.65). MolNFT v1 #17195 on GenesisL1: 3D structure…
- PDB
- 1OLO
- Type
- protein
- Length
- 499 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Regulatory protein repa
- UniProt
- P20356
- Ligands
- SO4
- Pockets
- 3 · best druggability 0.65
Structure
x-ray diffraction · 2 distinct chains · 36% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Regulatory protein repa | protein | 249 | 36% helix, 22% strand | P20356 |
| B | Regulatory protein repa | protein | 250 | 37% helix, 22% strand | P20356 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 399 | 0.65 | 0.79 | 45 | SO4 |
| 2 | 142 | 0.59 | 0.84 | 35 | empty |
| 3 | 54 | 0.28 | 0.74 | 20 | SO4 |
Interfaces
1 interface between chains.
- A–B · 1799 Ų buried · 22 hydrogen bonds · protein-protein
Compared structures
- 1OLO · Hexameric Replicative DNA Helicase RepA from Plasmid RSF1010 - Cubic Crystal Structure · the same entry in another collection · chain A against A, TM-score 1.00
- P20356 · AlphaFold monomer V2.0 prediction for regulatory protein repa (P20356) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P20356
- Elsewhere: RCSB PDB 1OLO · PDBe 1OLO · UniProt P20356
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